Description
Details
XAV939 is a potent and selective Wnt pathway antagonist. It functions to stabilize Axin by inhibiting tankyrase 1 and tankyrase 2 (IC50 = 11 nM and 4 nM, respectively). It has been used to study Wnt-dependent cancers. In addition, XAV939 has been shown to induce cardiomyocyte differentiation from mouse and human ESCs/iPSCs.
Details
Details
| Molecular Weight | 312.31 |
|---|---|
| Molecular Formula | C14H11F3N2OS |
| Chemical Name | 2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one |
| CAS Number | 284028-89-3 |
| PubChem Identifier | 2726824 |
| Appearance | White to off-white solid |
| Purity | >99% by HPLC analysis |
| Alternative Names | XAV-939, NVP-XAV 939 |
| Solubility | Soluble in DMSO at 10 mM |
| Reconstitution | For a 10 mM concentrated stock solution, reconstitute the compound by adding 640 μL of DMSO to the entire contents of vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes. |
| Storage and Stability | Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed. Solution: Following reconstitution, store aliquots in tightly sealed vials at -20°C. Avoid repeated freeze-thaw cycles. |
| References | Huang, S.M., et al. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461: 614-620. PMID: 19759537. Wang, H., et al. (2011) Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling. ACS Chem Biol 6: 192-197. PMID: 21077691. Willems, E., et al. (2011) Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm. Circ Res 109: 360-364. PMID: 21737789. |
| Technical Documents |