Description
Details
Selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). Selective for ALK5 over a range of kinases, including p38 MAPK, JNK1, and GSK3 (IC50 > 16 μM). RepSox has been shown to enhance the efficiency of cellular reprogramming and can replace Sox2 by inducing Nanog expression.
Details
Details
| Molecular Weight | 287.3 |
|---|---|
| Molecular Formula | C17H13N5 |
| Chemical Name | 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine |
| CAS Number | 446859-33-2 |
| PubChem Identifier | 449054 |
| Appearance | Yellow solid |
| Purity | >99% by HPLC analysis |
| Alternative Names | ALK5 Inhibitor II, 446859-33-2, ALK5 Inhibitor |
| Solubility | Soluble in DMSO at 100 mM |
| Reconstitution | For a 10 mM concentrated stock solution, reconstitute the compound by adding 1.74 mL of DMSO to the entire contents of vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes. |
| Storage and Stability | Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed. Solution: Following reconstitution, store aliquots in tightly sealed vials at -20°C. Avoid repeated freeze-thaw cycles. |
| References | Ichida, J.K., et al. (2009) A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell 5: 491-503. PMID: 19818703. Gellibert, F., et al. (2004) Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem 47: 4494-4506. PMID: 15317461. Solanki, A., et al. (2010) A step closer to complete chemical reprogramming for generating iPS cells. Chembiochem 11: 755-757. PMID: 20183843. |
| Technical Documents |