ESIBIO

  (877) 636-4978

Pyridone 6, 1 mg

Be the first to review this product

Pyridone 6 JAK Inhibitor I is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK1, JAK2, and JAK3.
SKU: ST10028
$140.00
 

Order Offline:

T: 877.636.4978
E: orders@esibio.com

F: 510.648.3255

 

Description

Details

JAK Inhibitor I is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK1, JAK2, and JAK3. Primary target: murine JAK1. JAK1 (Janus kinase 1), JAK2 and JAK3 belong to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated JAK1, JAK2 and JAK3.

Details

Details

Product Overview  
Molecular Weight 309.34
Molecular Formula C18H16FN3O
Chemical Name 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one
CAS Number 457081-03-7
PubChem Identifier 5494425
Appearance Off-white solid
Alternative Names JAK Inhibitor I, CMP 6, JAK Inhibitor
Preparation & Storage   
Solubility Soluble in DMSO at 5 mm
Reconstitution For powder format, reconstitute in DMSO to the desired concentration. For detailed instructions on reconstitution and use in cell culture please reference product data sheet.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed.
References 1. Pedranzini L, et al. (2006) Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res 66: 9714-9721. PMID: 17018630. 2. Kwak HB, et al. (2009) Pyridone 6, a pan-Janus-activated kinase inhibitor, suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression. Biol Pharm Bull 32: 45-50. PMID: 19122279.

Reviews

Write Your Own Review

You're reviewing: Pyridone 6, 1 mg

Tags

Tags

Use spaces to separate tags. Use single quotes (') for phrases.