Description
Details
JAK Inhibitor I is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK1, JAK2, and JAK3. Primary target: murine JAK1. JAK1 (Janus kinase 1), JAK2 and JAK3 belong to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated JAK1, JAK2 and JAK3.
Details
Details
| Product Overview | |
|---|---|
| Molecular Weight | 309.34 |
| Molecular Formula | C18H16FN3O |
| Chemical Name | 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one |
| CAS Number | 457081-03-7 |
| PubChem Identifier | 5494425 |
| Appearance | Off-white solid |
| Alternative Names | JAK Inhibitor I, CMP 6, JAK Inhibitor |
| Preparation & Storage | |
| Solubility | Soluble in DMSO at 5 mm |
| Reconstitution | For powder format, reconstitute in DMSO to the desired concentration. For detailed instructions on reconstitution and use in cell culture please reference product data sheet. |
| Storage and Stability | Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed. |
| References | 1. Pedranzini L, et al. (2006) Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res 66: 9714-9721. PMID: 17018630. 2. Kwak HB, et al. (2009) Pyridone 6, a pan-Janus-activated kinase inhibitor, suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression. Biol Pharm Bull 32: 45-50. PMID: 19122279. |