Description
Details
SB203580 is a selective p38 mitogen-activated protein kinase (MAPK) inhibitor (IC50 = 0.3 - 0.5 μM). It displays a 100 to 500 fold selectivity over LCK, GSK-3β and PKBα. SB203580 has been shown to enhance clonal growth of skin epithelial progenitor cells and to stimulate neural stem cell (NSC) proliferation.
Details
Details
| Molecular Weight | 377.44 |
|---|---|
| Molecular Formula | C21H16FN3OS |
| Chemical Name | 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole |
| CAS Number | 152121-47-6 |
| PubChem Identifier | 176155 |
| Appearance | Yellow solid |
| Purity | >96% by HPLC analysis |
| Alternative Names | SB-203580 |
| Solubility | Soluble in DMSO at 100 mM |
| Reconstitution | For a 10 mM concentrated stock solution, reconstitute the compound by adding 530 μL of DMSO to the entire contents of vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes. |
| Storage and Stability | Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed. Solution: Following reconstitution, store aliquots in tightly sealed vials at -20°C. Avoid repeated freeze-thaw cycles. |
| References | Borsch-Haubold, A.G., et al. (1998) Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J Biol Chem 273: 28766-28772. PMID: 9786874. Davies, S.P., et al. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351: 95-105. PMID: 10998351. Sato, K., et al. (2008) Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells. J Neurosci Res 86: 2179-2189. PMID: 18338804. |
| Technical Documents |