Description
Details
Purmorphamine is a small molecule that promotes the differentiation of human and murine mesenchymal progenitor cells into osteoblasts. The mechanism of action study of Purmorphamine indicates that it is an agonist of Smoothened, a 7-transmembrane receptor of the hedgehog signaling pathway. Purmorphamine can also be used to replace sonic hedgehog for the generation of motor neurons from human embryonic stem cells.
Details
Details
Product Overview | |
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Molecular Weight | 520.62 |
Molecular Formula | C31H32N6O2 |
Chemical Name | 2-(1-Naphthoxy)-6-(4-morpholinoanilino)- 9-cyclohexylpurine |
CAS Number | 483367-10-8 |
PubChem Identifier | 5284329 |
Appearance | Off-white solid |
Alternative Names | Shh Signaling Antagonist VI |
Preparation & Storage | |
Solubility | Soluble in DMSO at 50 mm |
Reconstitution | For powder form, reconstitute in DMSO to the desired concentration. For detailed instructions on reconstitution and use in cell culture please reference product data sheet. |
Storage and Stability | Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed. |
References | 1. Li XJ, et al. (2008) Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells 26: 886-893. PMID: 18238853. 2. Wu X, et al. (2004) Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol 11: 1229-1238. PMID: 15380183. |