Description
Details
Purmorphamine is a small molecule that promotes the differentiation of human and murine mesenchymal progenitor cells into osteoblasts. The mechanism of action study of Purmorphamine indicates that it is an agonist of Smoothened, a 7-transmembrane receptor of the hedgehog signaling pathway. Purmorphamine can also be used to replace sonic hedgehog for the generation of motor neurons from human embryonic stem cells.
Details
Details
| Product Overview | |
|---|---|
| Molecular Weight | 520.62 |
| Molecular Formula | C31H32N6O2 |
| Chemical Name | 2-(1-Naphthoxy)-6-(4-morpholinoanilino)- 9-cyclohexylpurine |
| CAS Number | 483367-10-8 |
| PubChem Identifier | 5284329 |
| Appearance | Off-white solid |
| Alternative Names | Shh Signaling Antagonist VI |
| Preparation & Storage | |
| Solubility | Soluble in DMSO at 50 mm |
| Reconstitution | For powder form, reconstitute in DMSO to the desired concentration. For detailed instructions on reconstitution and use in cell culture please reference product data sheet. |
| Storage and Stability | Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed. |
| References | 1. Li XJ, et al. (2008) Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells 26: 886-893. PMID: 18238853. 2. Wu X, et al. (2004) Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol 11: 1229-1238. PMID: 15380183. |