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PureStem® ES-210, Ecto-ntu Progenitor

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This clonal human embryonic progenitor line expresses markers of brain and nervous system related cells (TTR, ZIC2,TH,NES).
SKU: ES-210

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PureStem® ES-210, Ecto-ntu Progenitor expresses transthyretin (TTR), a marker of Blood Brain Barrier cells and choroid plexus making this progenitor valuable for research into diseases related to Cerebral Spinal Fluid including Alzheimer’s disease where defective choroid plexus function has been hypothesized. There is also up-regulation of genes associated with pancreatic beta cells, corneal tissues and genes associated with improper cardiac development. This progenitor was derived from the registered parental hES cell line H9 (WA09) as described (West et al, 2008).

Propagation Potential
PureStem Epithelial Progenitor T42 is sold at passage 12 (passage 1: original clonal isolate at confluence in 1.9 cm2 well), which corresponds to approximately 13.5 doublings since the first passage and approximately 31.5 doublings since its original clonal plating. The line displays a finite lifespan in vitro, and when properly maintained may reach 70 population doublings.



Applications Choroid plexus research and brain and choroid plexus-related disease research.
Quality Control This line is negative for HIV (1, 2), HBV, HCV, bacteria, mycoplasma, and fungal contamination. Certificates of analysis are available on request.
Technical Documents ES-210 Technical Data Sheet
References West MD, et al. (2008) The ACTCellerate initiative: large-scale combinatorial cloning of novel human embryonic stem cell derivatives. Regen Med. 3(3):287-308. PMID: 18462054


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