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LIF, Mouse Recombinant, 100 µg

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Promotes long-term maintenance of ESCs by suppressing spontaneous differentiation
SKU: ST12008

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Mouse recombinant Leukemia Inhibitory Factor (LIF) is a bioactive protein that promotes self-renewal and long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF is also involved in a wide variety of biological processes including neuronal survival and formation, control of stem cell pluripotency, hematopoietic cell proliferation, bone and fat metabolism, and promotion of megakaryocyte production in vivo. Mouse LIF is a 20 kDa protein containing 181 amino acid residues.



Concentration 100 µg/mL
Source E. coli
Species Mouse
Molecular Mass 20 kDa
Storage and Stability Store at 2-8°C. Stable for 6 months from date of receipt when stored as directed.
Formulation Sterile liquid in phosphate-buffered saline, 0.02% Tween 20, 1% BSA, and 0.22 μm filtered.
Purity Greater than 98% as determined by SDS-PAGE analysis
Endotoxin Level Less than 1.0 EU/μg of mouse LIF as determined by the LAL assay
Biological Activity Inhibits differentiation of mouse ES cells at 10 ng/mL
References Carpenter, M.K., et al. (2001) Enrichment of neurons and neural precursors from human embryonic stem cells. Exp Neurol 172(2): 383-397. PMID: 11716562

Gearing, D.P., et al. (1987) Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO J 6(13): 3995-4002. PMID: 3127201

Metcalf, D. (2003) The unsolved enigmas of leukemia inhibitory factor. Stem Cells 21(1): 5-14. PMID: 12529546
Technical Documents

ST12008 Technical Data Sheet


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