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3-Deazaneplanocin A, 10 mM

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Epigenetic modifier inhibits EZH2 histone methyltransferase
SKU: ST10022

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3-Deazaneplanocin A (DZNep) acts as an epigenetic modifier that inhibits histone methyltransferases and decreases global DNA methylation. It is a competitive inhibitor of S-adenosylhomocysteine hydrolase (Ki = 50 pM). It has been specifically shown to inhibit EZH2 protein expression which reduces the trimethylation of lysine 27 on histone H3. When used in combination with other compounds, DZNep can enable chemical reprogramming of mouse embryonic fibroblasts to iPSCs by increasing Oct4 expression.



Molecular Weight 262.26
Molecular Formula C12H14N4O3
Chemical Name (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
CAS Number 102052-95-9
PubChem Identifier 73087
Appearance Colorless liquid
Purity >97% by HPLC analysis
Size 400 μL, 10 mM in DMSO
Alternative Names DZNep
Storage and Stability Store at -20°C. Stable for 6 months when stored as directed. Avoid repeated freeze-thaw cycles.
References Hou, P., et al. (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341(6146): 651-654. PMID: 23868920.

Miranda, T.B., et al. (2009) DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol Cancer Ther 8(6): 1579-1588. PMID: 19509260.

Tan, J., et al. (2007) Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 21(9): 1050-1063. PMID: 17437993.

Tseng, C.K., et al. (1989) Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities. J Med Chem 32(7): 1442-1446. PMID: 2544721.
Technical Documents

ST10022 Technical Data Sheet


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