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LY411575, 5 mg

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Notch pathway inhibitor targeting γ-secretase
SKU: ST10035

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LY411575 is a selective γ-secretase inhibitor which indirectly suppresses Notch activation. It has been shown to promote goblet cell differentiation in mouse intestine. LY411575 is known to support neural differentiation of mouse ES cells. It has also been used to inhibit cell proliferation in primary and immortalized Kaposi's sarcoma cells.



Molecular Weight 479.48
Molecular Formula C26H23F2N3O4
Chemical Name (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide
CAS Number 209984-57-6
PubChem Identifier 10435235
Appearance White solid
Purity >99% by HPLC analysis
Solubility Soluble in DMSO at 100 mM and ethanol at 100 mM
Reconstitution For a 10 mM concentrated stock solution, reconstitute the compound by adding 1.04 mL of DMSO to the entire contents of vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed. Solution:Following reconstitution, store aliquots in tightly sealed vials at -20°C. Avoid repeated freeze-thaw cycles.
References Abranches, E., et al. (2009) Neural differentiation of embryonic stem cells in vitro: a road map to neurogenesis in the embryo. PLoS One 4(7): e6286. PMID: 19621087.

Curry, C.L., et al. (2005) Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene 24(42): 6333-6344. PMID: 15940249.

McKee, T.D., et al. (2013) An improved cell-based method for determining the γ-secretase enzyme activity against both Notch and APP substrates. J Neurosci Methods 213(1): 14-21. PMID: 23219895.

Wong, G.T., et al. (2004) Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem 279(13): 12876-12882. PMID: 14709552.
Technical Documents

ST10035 Technical Data Sheet


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