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Potent inhibitor of MEK1/2.
Product Name SKU Price Qty
PD0325901, 2 mg ST10008
PD0325901, 10 mg ST10009
PD0325901, 415 µL / 10 mM ST10010

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PD0325901 is a small molecule targeting mitogen-activated protein kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. PD0325901 has been shown to increase the efficiency of reprogramming human primary fibroblasts into induced pluripotent stem cells.



Molecular Weight 482.19
Molecular Formula C16H14F3IN2O4
Chemical Name N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
CAS Number 391210-10-9
PubChem Identifier 9826528
Purity >99% by HPLC
Alternative Names PD325901, MEK1/2 Inhibitor III
Solubility Soluble in DMSO at 25 mM
Reconstitution For powder form, reconstitute in DMSO to the desired concentration. For detailed instructions on reconstitution and use in cell culture please reference technical data sheet.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed.
10 mM Solution: Shipped on dry ice. Store at -20°C. Avoid repeated freeze-thaw cycles. Stable for 6 months when stored as directed.
References Barrett, S.D., et al. (2008) The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett 18: 6501-6504. PMID: 18952427.

Lin, T., et al. (2009) A chemical platform for improved induction of human iPSCs. Nat Methods 6: 805-808. PMID: 19838168.

Sebolt-Leopold, J.S., et al. (2004) Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 4: 937-947. PMID: 15573115.
Technical Documents ST10008 Technical Data Sheet
ST10009 Technical Data Sheet
ST10010 Technical Data Sheet


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