Description
Details
PD0325901 is a small molecule targeting mitogen-activated protein kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. PD0325901 has been shown to increase the efficiency of reprogramming human primary fibroblasts into induced pluripotent stem cells.
Details
Details
| Molecular Weight | 482.19 |
|---|---|
| Molecular Formula | C16H14F3IN2O4 |
| Chemical Name | N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide |
| CAS Number | 391210-10-9 |
| PubChem Identifier | 9826528 |
| Purity | >99% by HPLC |
| Alternative Names | PD325901, MEK1/2 Inhibitor III |
| Solubility | Soluble in DMSO at 25 mM |
| Reconstitution | For powder form, reconstitute in DMSO to the desired concentration. For detailed instructions on reconstitution and use in cell culture please reference technical data sheet. |
| Storage and Stability | Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed. 10 mM Solution: Shipped on dry ice. Store at -20°C. Avoid repeated freeze-thaw cycles. Stable for 6 months when stored as directed. |
| References | Barrett, S.D., et al. (2008) The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett 18: 6501-6504. PMID: 18952427. Lin, T., et al. (2009) A chemical platform for improved induction of human iPSCs. Nat Methods 6: 805-808. PMID: 19838168. Sebolt-Leopold, J.S., et al. (2004) Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 4: 937-947. PMID: 15573115. |
| Technical Documents | ST10008 Technical Data Sheet ST10009 Technical Data Sheet ST10010 Technical Data Sheet |
