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XAV939, 2 mg

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Wnt pathway inhibitor through Tankyrase inhibition.
SKU: ST10017
$100.00
 

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Description

Details

XAV939 is a potent and selective Wnt pathway antagonist. It functions to stabilize Axin by inhibiting tankyrase 1 and tankyrase 2 (IC50 = 11 nM and 4 nM, respectively). It has been used to study Wnt-dependent cancers. In addition, XAV939 has been shown to induce cardiomyocyte differentiation from mouse and human ESCs/iPSCs.

Details

Details

Molecular Weight 312.31
Molecular Formula C14H11F3N2OS
Chemical Name 2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
CAS Number 284028-89-3
PubChem Identifier 2726824
Appearance White to off-white solid
Purity >99% by HPLC analysis
Alternative Names XAV-939, NVP-XAV 939
Solubility Soluble in DMSO at 10 mM
Reconstitution For a 10 mM concentrated stock solution, reconstitute the compound by adding 640 μL of DMSO to the entire contents of vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed.
Solution: Following reconstitution, store aliquots in tightly sealed vials at -20°C. Avoid repeated freeze-thaw cycles.
References Huang, S.M., et al. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461: 614-620. PMID: 19759537.

Wang, H., et al. (2011) Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling. ACS Chem Biol 6: 192-197. PMID: 21077691.

Willems, E., et al. (2011) Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm. Circ Res 109: 360-364. PMID: 21737789.
Technical Documents

ST10017 Technical Data Sheet

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