Description
Details
PD173074 is an ATP-competitive FGFR1 and FGFR3 inhibitor (IC50 = 21.5 and 5 nM respectively) and also inhibits FGFR2, FGFR4, and VEGFR2. Through its interaction with FGF receptors, it has been found to suppress tumor growth. PD173074 has also been shown to inhibit proliferation and differentiation of oligodendrocyte progenitors. It suppresses the differentiation of mouse ESCs and maintains the undifferentiated state. In human ESCs, PD173074 has been shown to promote differentiation or maintenance in a naïve state.
Details
Details
| Molecular Weight | 523.67 |
|---|---|
| Molecular Formula | C28H41N7O3 |
| Chemical Name | 1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea |
| CAS Number | 219580-11-7 |
| PubChem Identifier | 1401 |
| Appearance | Yellow solid |
| Purity | >97% by HPLC analysis |
| Solubility | Soluble in DMSO at 100 mM and ethanol at 100 mM |
| Reconstitution | For a 10 mM concentrated stock solution, reconstitute the compound by adding 382 µL of DMSO to the entire contents of vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes. |
| Storage and Stability | Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed. Solution: Following reconstitution, store aliquots in tightly sealed vials at -20°C. Avoid repeated freeze-thaw cycles. |
| References | Hanna, J., et al. (2010) Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci USA 107(20): 9222-9227. PMID: 20442331. Mohammadi, M., et al. (1998) Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J 17(20): 5896-5904. PMID: 9774334. Ying, Q.L., et al. (2008) The ground state of embryonic stem cell self-renewal. Nature 453(7194): 519-523. PMID: 18497825. |
| Technical Documents |