Description
Details
SB431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. It suppresses TGF-β-induced proliferation of human osteosarcoma cells. SB431542 has been shown to stimulate proliferation, differentiation, and sheet formation of ESC-derived endothelial cells.
Details
Details
| Molecular Weight | 384.39 |
|---|---|
| Molecular Formula | C22H16N4O3 |
| Chemical Name | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide |
| CAS Number | 301836-41-9 |
| PubChem Identifier | 4521392 |
| Purity | >98% by HPLC analysis |
| Solubility | Soluble in DMSO at 100 mM and ethanol at 10 mM |
| Reconstitution | For powder form, reconstitute in DMSO to the desired concentration. For detailed instructions on reconstitution and use in cell culture please reference technical data sheet. |
| Storage and Stability | Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed. 10 mM Solution: Shipped on dry ice. Store at -20°C. Avoid repeated freeze-thaw cycles. Stable for 6 months when stored as directed. |
| References | Laping, N.J., et al. (2002) Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol 62: 58-64. PMID: 12065755. Watabe, T., et al. (2003) TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J Cell Biol 163: 1303-1311. PMID: 14676305 |
| Technical Documents | ST10012 Technical Data Sheet ST10013 Technical Data Sheet ST10014 Technical Data Sheet |
