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Highly selective GSK-3 inhibitor.
Product Name SKU Price Qty
CHIR99021, 2 mg ST10003
CHIR99021, 10 mg ST10004
CHIR99021, 430 µL / 10 mM ST10005

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CHIR99021 is the most widely used, potent and selective inhibitor of glycogen synthase kinase 3 (GSK-3), inhibiting GSK-3β (IC50 = 6.7 nM) and GSK-3α (IC50 = 10 nM). It exhibits greater than 500-fold selectivity for GSK-3 over closely related kinases. CHIR99021 has been shown to enhance the reprogramming of murine and human somatic cells into iPSCs, potently promote expansion of ESCs and tissue-specific adult stem cells and induce differentiation of human ESCs/iPSCs toward neural or mesendoderm lineages under appropriate conditions.



Molecular Weight 465.34
Molecular Formula C22H18Cl2N8
Chemical Name 6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile
CAS Number 252917-06-9
PubChem Identifier 9956119
Purity >97% by HPLC analysis
Alternative Names CT99021, GSK-3 Inhibitor XVI
Solubility Soluble in DMSO at 100 mM
Reconstitution For powder form, reconstitute in DMSO to the desired concentration. For detailed instructions on reconstitution and use in cell culture please reference technical data sheet.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed.
10 mM Solution: Shipped on dry ice. Store at -20°C. Avoid repeated freeze-thaw cycles. Stable for 6 months when stored as directed.

Li, W., et al. (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27: 2992-3000. PMID: 19839055.

Ring, D.B., et al. (2003) Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 52: 588-595. PMID: 12606497.

Ying, Q., et al. (2008) The ground state of embryonic stem cell self-renewal. Nature 453: 519-523. PMID: 18497825.

Technical Documents

ST10003 Technical Data Sheet

ST10004 Technical Data Sheet

ST10005 Technical Data Sheet


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