(877) 636-4978


Be the first to review this product

Selective inhibitor of TGF-βRI, ALK4 and ALK7.
Product Name SKU Price Qty
A83-01, 2 mg ST10001
A83-01, 10 mg ST10002

Order Offline:

T: 877.636.4978

F: 510.648.3255




Selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). A83-01 blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. A83-01 has been shown to inhibit differentiation of rat iPSCs and increase clonal expansion efficiency. It helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs.



Molecular Weight 421.52
Molecular Formula C25H19N5S
Chemical Name 3-(6-Methyl-2-pyridinyl)-N-phenyl-4​-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
CAS Number 909910-43-6
PubChem Identifier 16218924
Appearance Pale yellow solid
Purity >96% by HPLC Analysis
Solubility Soluble in DMSO at 50 mM
Reconstitution For powder form, reconstitute in DMSO to the desired concentration. For detailed instructions on reconstitution and use in cell culture please reference technical data sheet.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed.
Solution: Following reconstitution, store aliquots in tightly sealed vials at -20°C. Avoid repeated freeze-thaw cycles.
References Hoberg, M., et al. (2008) Attachment to laminin-111 facilitates transforming growth factor β-induced expression of matrix metalloproteinase-2 in synovial fibroblasts. Ann Rheum Dis 66: 446-451. PMID: 17124250.

Li, W., et al. (2009) Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 4: 16-19. PMID: 19097958.

Tojo, M., et al. (2005) The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci 96: 791-800. PMID: 16271073.
Technical Documents

ST10001 Technical Data Sheet
ST10002 Technical Data Sheet


Write Your Own Review

You're reviewing: A83-01



Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.